Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 498-62-4, Name is Thiophene-3-carbaldehyde, SMILES is O=CC1=CSC=C1, belongs to indole-building-block compound. In a document, author is Ruan, Hongli, introduce the new discover, Computed Properties of C5H4OS.
WATER ASSISTED AND CHOLINE CHLORIDE-DIMETHYLUREA DEEP EUTECTIC SALTS AS CATALYST TOWARDS THE ATTRACTIVE REACTION OF INDOLE, BENZALDEHYDE, AND MALONONITRILE
The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 498-62-4 is helpful to your research. Computed Properties of C5H4OS.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles