Qi, Liang-Wen published the artcileOrganocatalytic asymmetric arylation of indoles enabled by azo groups, Recommanded Product: 2-(tert-Butyl)-5-chloro-1H-indole, the main research area is organocatalytic asym arylation indole azo directing activating group; nucleophilic aromatic substitution asym organocatalytic; pyrroloindole preparation asym arylation azo directing activating group; arylindole preparation asym arylation azo directing activating group.
Arylation is a fundamental reaction that can be mostly fulfilled by electrophilic aromatic substitution and transition-metal-catalyzed aryl functionalization. Although the azo group has been used as a directing group for many transformations via transition-metal-catalyzed aryl carbon-hydrogen (C-H) bond activation, there remain significant unmet challenges in organocatalytic arylation. Here, we show that the azo group can effectively act as both a directing and activating group for organocatalytic asym. arylation of indoles via formal nucleophilic aromatic substitution of azobenzene derivatives Thus, a wide range of axially chiral arylindoles, e.g., I and II, have been achieved in good yields with excellent enantioselectivities by utilizing chiral phosphoric acid as catalyst. Furthermore, highly enantioenriched pyrroloindoles, e.g., III, bearing two contiguous quaternary chiral centers, have also been obtained via a cascade enantioselective formal nucleophilic aromatic substitution-cyclization process. This strategy should be useful in other related research fields and will open new avenues for organocatalytic asym. aryl functionalization.
Nature Chemistry published new progress about Arylation catalysts, stereoselective. 69622-40-8 belongs to class indole-building-block, name is 2-(tert-Butyl)-5-chloro-1H-indole, and the molecular formula is C12H14ClN, Recommanded Product: 2-(tert-Butyl)-5-chloro-1H-indole.
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