On June 30, 2006, Qian, Chao; Zhang, Jia-sen; Liu, Jian-qing; Li, Lu-zhen; Chen, Xin-zhi published an article.Reference of H-Idc-OH The title of the article was Study on the synthesis of S-(-)-2-Carboxyindoline. And the article contained the following:
A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Reference of H-Idc-OH
The Article related to carboxyindoline preparation nitrotoluene chiral resolution carnitine oxalate, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Reference of H-Idc-OH
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles