Qian, Chenxiao; Liu, Meiwen; Sun, Jianwei; Li, Pengfei published the artcile< Chiral phosphoric acid-catalyzed regio- and enantioselective reactions of functionalized propargylic alcohols>, Synthetic Route of 4771-48-6, the main research area is spiro isoindoline pyrroloindolone preparation regioselective enantioselective.
Here, the scope of propargylic alcs. and the power of CPA catalysis was expanded. With the established system, racemic 3-alkynyl-3-hydroxyisoindolinones reacted efficiently to form diverse spirocyclic heterocycles I [R1 = Ph, 4-BrC6H4, 2-thienyl, etc.; R2 = Me, Ph; R3 = H, 5-Me, 6-F, etc.] with high enantioselectivity. Regiodivergence was also observed with different indole nucleophiles. Importantly, the key covalently bonded CPA adduct was isolated, characterized and further confirmed to be chem. competent, and a possible covalent activation mode was proposed accordingly.
Organic Chemistry Frontiers published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Synthetic Route of 4771-48-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles