Qin, Hong; Zhang, Jie; Qiao, Kai; Zhang, Dong; He, Wei; Liu, Chengkou; Fang, Zheng; Guo, Kai published an article in 2021. The article was titled 《Palladium-Catalyzed C2-Regioselective Perfluoroalkylation of the Free (NH)-Heteroarenes》, and you may find the article in Journal of Organic Chemistry.Related Products of 399-52-0 The information in the text is summarized as follows:
A highly regioselective and atom-efficient strategy for the construction of fused free (NH) heteroarenes I (R = 3-Me, 4-Cl, 7-F, etc.) and II (R1 = 2-C(O)2Me, 3-C(O)2Me, 3-C(O)2Et-4-Me) through a palladium-catalyzed perfluoroalkyl insertion reaction has been accomplished. This protocol employed multiple iodofluoroalkanes R2I [R2 = 1,2,2,3,3,4,4,5,5,6,6-undecafluorocyclohexyl, 1,1,2,2,3,3,3-heptafluoropropyl, (benzenesulfonyl)difluoromethyl, etc.] as practical and available perfluoroalkyl sources to provide an operationally simple and versatile route for the synthesis of perfluoroalkylated indoles III. Moreover, indoles I without the assistance of guide groups were utilized as substrates, achieving C(sp2)-H site-selective functionalization of indoles I in yields up to 95%. Furthermore, this protocol was also used for late-stage C2 perfluoroalkylation of bioactive compounds such as auxin, tryptophan, and melatonin analogs. The experimental part of the paper was very detailed, including the reaction process of 5-Fluoro-1H-indole(cas: 399-52-0Related Products of 399-52-0)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Related Products of 399-52-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles