Qiu, Di published the artcileSynthesis of Pinacol Arylboronates from Aromatic Amines: A Metal-Free Transformation, Safety of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, the publication is Journal of Organic Chemistry (2013), 78(5), 1923-1933, database is CAplus and MEDLINE.
A metal-free borylation process based on Sandmeyer-type transformation using arylamines derivatives as the substrates was developed. Through optimization of the reaction conditions, this novel conversion can be successfully applied to a wide range of aromatic amines, affording borylation products in moderate to good yields. Various functionalized arylboronates, which are difficult to access by other methods, can be easily obtained with this metal-free transformation. Also, this transformation can be followed by Suzuki-Miyaura cross-coupling without purification of the borylation products, which enhances the practical usefulness of this method. A possible reaction mechanism involving radical species is proposed.
Journal of Organic Chemistry published new progress about 642494-36-8. 642494-36-8 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Indole,Boronate Esters,Boronic acid and ester, name is 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole, and the molecular formula is C14H18BNO2, Safety of 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
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