Rahim, Abdul et al. published their research in Medicinal Chemistry Research in 2019 | CAS: 827-01-0

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 827-01-0

Synthesis and biological evaluation of phenyl-amino-pyrimidine and indole/oxindole conjugates as potential BCR-ABL inhibitors was written by Rahim, Abdul;Syed, Riyaz;Poornachandra, Y.;Malik, M. Shaheer;Reddy, Ch. Venkata Ramana;Alvala, Mallika;Boppana, Kiran;Sridhar, B.;Amanchy, Ramars;Kamal, Ahmed. And the article was included in Medicinal Chemistry Research in 2019.HPLC of Formula: 827-01-0 This article mentions the following:

Indole/isatin conjugated phenyl-amino-pyrimidine derivatives have been synthesized, characterized and evaluated in vitro for their potential as BCR-ABL inhibitors. Among the series, all derivatives (7a-7o) were found to be more cytotoxic than standard Imatinib against K-562 cell line. Compound 7l(I) was the most active in the series with almost two folds more potency than imitanib (IC50 0.65 μM). In vitro enzymic studies with recombinant ABL kinase enzyme exhibited promising inhibition in the range of 30-71 μM for most of these novel conjugates. In addition, modeling and other computational studies have been carried out to draw insight into the BCR-ABL protein interactions with the target mols. and drug like properties of the conjugates, resp. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0HPLC of Formula: 827-01-0).

5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 827-01-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles