Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study was written by Rana, Sandeep;Blowers, Elizabeth C.;Tebbe, Calvin;Contreras, Jacob I.;Radhakrishnan, Prakash;Kizhake, Smitha;Zhou, Tian;Rajule, Rajkumar N.;Arnst, Jamie L.;Munkarah, Adnan R.;Rattan, Ramandeep;Natarajan, Amarnath. And the article was included in Journal of Medicinal Chemistry in 2016.Electric Literature of C10H9NO2 The following contents are mentioned in the article:
Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogs and their evaluation as anticancer agents is described. SAR identified a spirocyclic analog I that inhibited TNFα-induced NF-κB activity, cancer cell growth and tumor growth in an ovarian cancer model. A second iteration of synthesis and screening identified II which inhibited cancer cell growth with low-μM potency. Our data suggest that an isatin-derived spirocyclic α-methylene-γ-butyrolactone is a suitable core for optimization to identify novel anticancer agents. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Electric Literature of C10H9NO2).
4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C10H9NO2
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles