Antibacterial and cytotoxic activity of 2,21-(5,5′-methylene bis (1,3,4-oxadiazole-5,2-diyl) bis (sulfanediyl) bis(N’-(2-oxoindolin-3-ylidene) acetohydrazides was written by Rani, S. Shobha;Agaiah, Bairi;Sarangapani, M.. And the article was included in International Journal of Chemical Sciences in 2010.Application In Synthesis of 7-Nitroindoline-2,3-dione This article mentions the following:
2,21-5,5′-Methylene bis(1,3,4-oxadiazole-5,2-diyl)bis(sulfanediyl)bis(N’-(2oxoindolin-3-ylidene) acetohydrazides) (VIa-o) have been synthesized by the condensation of 2-chloro-N1(2-oxo-1,2-dihydro-3H-indole-3-ylidene)acetohydrazides (IVa-o) with the intermediate 5,51-methylene diyl bis(1,3,4-oxadiazole-2-thiol) (V). All the title compounds (VIa-o) were screened for cytotoxic activity using A-549 lung cancer and HT-29 colon cancer cell lines by MTT method and antimicrobial activity against B. subtilis, S. aureus, E. coli and S. typhi. The structures of newly synthesized compounds were established on the basis of elemental anal., IR, 1H NMR and mass spectral data. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Application In Synthesis of 7-Nitroindoline-2,3-dione).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of 7-Nitroindoline-2,3-dione
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles