Antioxidant and DNA binding study of 2,21-(5,5′-methylenebis(1,3,4-oxadiazole-5,2-diyl)bis(sulfanyl)acetic acid bis(2-oxo-3-indolyl)hydrazides was written by Rani, S. Shobha;Agaiah, Bairi;Sarangapani, M.. And the article was included in International Journal of Chemical Sciences in 2010.COA of Formula: C8H4N2O4 This article mentions the following:
The synthesis of the target compounds was achieved by a reaction of 1H-indole-2,3-dione derivatives with hydrazine and chloroacetyl chloride, formation of 2-chloroacetic acid 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide derivatives, subsequent reaction with 5,5′-methylenebis[1,3,4-oxadiazole-2(3H)-thione] and the products thus obtained were confirmed by elemental anal., IR, NMR, MS. The title compounds were evaluated for their radical scavenging properties using a DPPH radical model [2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazinyl radical] and it was discovered that these compounds displayed antioxidant activity in comparison with ascorbic acid. The compounds were also evaluated in a herring sperm DNA model and it was discovered that these products displayed DNA binding properties in using cisplatin as a drug standard In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8COA of Formula: C8H4N2O4).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). COA of Formula: C8H4N2O4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from鑱紹acillus thuringiensis鑱絘nd鑱紹acillus velezensis鑱絘nd their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles