A quick and regioselective access of spirooxindole-oxazoline by reaction of isatin and isocyanoacetate “on water” was written by Rankan, Chandran;Santhi Marimuthu, Prabhakaran;Tiwari, Keshri Nath. And the article was included in Journal of Heterocyclic Chemistry in 2020.Application of 723-89-7 This article mentions the following:
A greener, rapid and regioselective “on water” synthesis of spirooxindole-oxazoline by the reaction of isatin and isocyanoacetate at room temperature was described. The developed protocol has the advantage of being atom-economical, eco-friendly and benign reaction conditions. Broader substrate scope, exptl. simple procedures and easy purification of products with high yield further make this method attractive. The synthesized compounds were fully characterized with spectral anal. In the experiment, the researchers used many compounds, for example, 1-Phenylindoline-2,3-dione (cas: 723-89-7Application of 723-89-7).
1-Phenylindoline-2,3-dione (cas: 723-89-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Application of 723-89-7
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles