A facile and green synthesis of novel imide and amidic acid derivatives of phenacetin as potential analgesic and anti-pyretic agents was written by Reddy, Yervala D.;Kumar, Padam P.;Devi, Bhoomireddy R.;Dubey, Pramod K.;Kumari, Yalamanchili B.. And the article was included in Letters in Organic Chemistry in 2013.COA of Formula: C8HBr4NO2 This article mentions the following:
Facile and green syntheses of potential analgesic and antipyretic compounds, N-(4-ethoxyphenyl)-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide derivatives and N-[(4-ethoxyphenylcarbamoyl)methyl]phthalamic acid derivatives have been developed. Two synthetic routes (A and B) have been established for the preparation of the former. In the route-A, 4-ethoxyaniline was reacted with chloroacetyl chloride in a solution of potassium acetate and acetic acid to yield N-(4-ethoxyphenyl)-2-chloroacetamide. The latter was reacted with imide compounds either in triethanolamine as a green solvent or in solid phase in the presence of TEBAC and KI to yield the products. Alternatively, in the route-B, reaction of anhydrides with glycine yielded the (1,3-dioxo-1,3-dihydroisoindol-2-yl)acetic acid derivatives which on reaction with 4-ethoxyaniline either in triethnolamine and DCC as a dehydrating agent or in solid phase in the presence of DCC gave the products. The latter were hydrolyzed in 0.5N ethanolic KOH to afford N-[(4-ethoxyphenylcarbamoyl)methyl]phthalamic acid derivatives In the experiment, the researchers used many compounds, for example, 4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7COA of Formula: C8HBr4NO2).
4,5,6,7-Tetrabromoisoindoline-1,3-dione (cas: 24407-32-7) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.COA of Formula: C8HBr4NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles