The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole(SMILESS: C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1,cas:2208-59-5) is researched.SDS of cas: 76-60-8. The article 《An advantageous synthesis of 2-substituted benzimidazoles using polyphosphoric acid. 2-(Pyridyl)-1H-benzimidazoles, 1-alkyl-(1H-benzimidazol-2-yl)pyridinium salts, their homologs and vinylogs.》 in relation to this compound, is published in Synthesis. Let’s take a look at the latest research on this compound (cas:2208-59-5).
The title benzimidazoles I [R = H, Me, X = (CH2)n, (E)-CH:CH, n = 0,1] were prepared by a highly efficient one-pot procedure, cyclodehydration of the corresponding accessible carboxylic acids and 1,2-arylenediamines using polyphosphoric acid as the catalyst and solvent in a condensation of the type found in the Phillips benzimidazole synthesis. The method was adapted and proved to be extremely useful for 1-alkyl-(1H-benzimidazol-2-yl)pyridinium tetrafluoroborates with a methylene and vinylene interannular moiety.
In addition to the literature in the link below, there is a lot of literature about this compound(2-(Pyridin-4-yl)-1H-benzo[d]imidazole)Safety of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, illustrating the importance and wide applicability of this compound(2208-59-5).
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles