Ruel, Rejean; Thibeault, Carl; L’Heureux, Alexandre; Martel, Alain; Cai, Zhen-Wei; Wei, Donna; Qian, Ligang; Barrish, Joel C.; Mathur, Arvind; D’Arienzo, Celia; Hunt, John T.; Kamath, Amrita; Marathe, Punit; Zhang, Yueping; Derbin, George; Wautlet, Barri; Mortillo, Steven; Jeyaseelan, Robert Sr.; Henley, Benjamin; Tejwani, Ravindra; Bhide, Rajeev S.; Trainor, George L.; Fargnoli, Joseph; Lombardo, Louis J. published the artcile< Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor>, Name: 5-Nitro-1H-pyrrolo[2,3-b]pyridine, the main research area is BMS 645737 preparation structure VEGFR inhibitor antitumor.
The authors report herein a series of substituted N-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amines as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase. Through structure-activity relationship studies, biochem. potency, pharmacokinetics, and kinase selectivity were optimized to afford BMS-645737 (I), a compound with good preclin. in vivo activity against human tumor xenograft models.
Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 101083-92-5 belongs to class indole-building-block, and the molecular formula is C7H5N3O2, Name: 5-Nitro-1H-pyrrolo[2,3-b]pyridine.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles