Ruiz, Nerea; Reyes, Efraim; Vicario, Jose L.; Badia, Dolores; Carrillo, Luisa; Uria, Uxue published an article in 2008, the title of the article was Organocatalytic enantioselective synthesis of highly functionalized polysubstituted pyrrolidines.Reference of H-Idc-OH And the article contains the following content:
The organocatalytic conjugate addition of different aldehydes to β-nitroacrolein di-Me acetal, generating the corresponding highly functionalized nitroaldehydes in high yields and with high stereoselectivities, has been studied in detail. These transformations have been achieved by using both readily available starting materials in a 1:1 ratio as well as com. available catalysts at a 10 mol% catalyst loading. Furthermore, a very short and efficient protocol has been devised for the preparation of highly enantioenriched pyrrolidines containing two or three contiguous stereocenters starting from the obtained Michael adducts. 3,4-Disubstituted pyrrolidines have been obtained in a single step by Zn-mediated chemoselective reduction of the nitro group followed by intramol. reductive amination, and trisubstituted homoproline derivatives have been prepared by means of an olefination reaction and a cascade process involving chemoselective reduction of the nitro group followed by a fully diastereoselective intramol. aza-Michael reaction. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Reference of H-Idc-OH
The Article related to beta nitroacrolein dimethyl acetal aldehyde chiral organocatalyst conjugate addition, aldehyde nitro derivative stereoselective preparation reduction intramol reductive amination, nitroaldehyde derivative stereoselective preparation olefination reduction intramol aza michael, pyrrolidine polysubstituted derivative chemoselective stereoselective preparation and other aspects.Reference of H-Idc-OH
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles