On March 31, 1990, Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi published an article.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Condensed heteroaromatic ring systems. XVII. Palladium-catalyzed cyclization of β-(2-halophenyl)amino substituted α,β-unsaturated ketones and esters to 2,3-disubstituted indoles. And the article contained the following:
Palladium-catalyzed cyclization of β-(2-halophenyl)amino substituted α,β-unsaturated ketones and esters, prepared from 2-haloanilines by three different methods, gave 2,3-disubstituted indoles. Thus, conductivity of 2-IC6H4NH2 with AcCH2Ac in C6H6 containing catalyst 4-MeC6H4SO3H gave 72% 2-IC6H4NHCMe:CHCOMe which on cyclization with Pd(OAc)2 in Et3N-DMF in a sealed tube (120°, 6 h) gave 49% 3-acetyl-2-methylindole. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate
The Article related to halophenylaminoalkenone preparation palladium catalyzed cyclization, acylindole, indole acyl, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles