Sall, Daniel J. published the artcileUse of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists, Quality Control of 104291-81-8, the main research area is bicyclic amidine preparation platelet receptor antagonist; glycoprotein platelet receptor antagonist bicyclic amidine.
The use of 5,6-bicyclic amidines, e.g., I, as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor antagonists is described. The addnl. conformational restriction offered by the bicyclic nucleus results in 20-400-fold increases in potency compared to the freely flexible, acyclic benzamidine counterpart. The design, synthesis, structure-activity relationships (SAR), and in vitro activity of this novel class of GPIIb-IIIa antagonists are presented.
Journal of Medicinal Chemistry published new progress about Blood platelet. 104291-81-8 belongs to class indole-building-block, name is Ethyl 6-cyano-1H-indole-2-carboxylate, and the molecular formula is C12H10N2O2, Quality Control of 104291-81-8.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles