Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents was written by Sashidhara, Koneni V.;Dodda, Ranga Prasad;Sonkar, Ravi;Palnati, Gopala Reddy;Bhatia, Gitika. And the article was included in European Journal of Medicinal Chemistry in 2014.Application In Synthesis of 5-Chloroindole-3-carboxaldehyde This article mentions the following:
A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that three hybrids, e.g., I, exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. The results results suggest that these new hybrid scaffolds may serve as promising leads for the development of next generation lipid lowering agents. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Application In Synthesis of 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Application In Synthesis of 5-Chloroindole-3-carboxaldehyde
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Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles