Recommanded Product: Benzyl Alcohol. Bonnac, LF; Dreis, CD; Geraghty, RJ in [Bonnac, Laurent F.; Dreis, Christine D.; Geraghty, Robert J.] Univ Minnesota, Coll Pharm, Ctr Drug Design, NHH, 312 Church St SE, Minneapolis, MN 55455 USA published Structure activity relationship, 6-modified purine riboside analogues to activate hSTING, stimulator of interferon genes in 2020.0, Cited 19.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
Twenty-nine nucleoside analogues have been synthesized and evaluated in a cell based assay for their ability to activate the human Stimulator of Interferon Genes (hSTING), a key protein of the innate immune defense. Some 6-O-alkyl nucleoside analogues activate hSTING without associated cytotoxicity. SAR and combination studies were performed to decipher possible activation mechanism. The described nucleoside hSTING activators represent first-in-class modulators of the innate immune defense; a highly relevant target for antiviral, antibacterial, anticancer or Alzheimer’s disease treatments and may present advantages over other types of hSTING activators.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles