An article Low-Dose X-ray-Responsive Diselenide Nanocarriers for Effective Delivery of Anticancer Agents WOS:000577111700006 published article about HYDROGEN-PEROXIDE; POLYMERIC NANOPARTICLES; RADIATION-THERAPY; BASIS-SETS; CANCER; CHEMOTHERAPY; RELEASE; RADIOTHERAPY; COMBINATION; EFFICACY in [Zhang, Lianxue; Zhang, Shitong; Xu, Jiaying; Li, Youyun; Yang, Ying; Duan, Guangxin; Yang, Zaixing; Zhou, Ruhong] Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China; [Zhang, Lianxue; Zhang, Shitong; Xu, Jiaying; Li, Youyun; Yang, Ying; Duan, Guangxin; Yang, Zaixing; Zhou, Ruhong] Soochow Univ, Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, Suzhou 215123, Peoples R China; [He, Jinlin] Soochow Univ, Coll Chem Chem Engn & Mat Sci, State & Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China; [Huynh, Tien; Ni, Peihong; Zhou, Ruhong] IBM Thomas J Watson Res Ctr, Computat Biol Ctr, Yorktown Hts, NY 10598 USA; [Zhou, Ruhong] Columbia Univ, Dept Chem, New York, NY 10027 USA in 2020.0, Cited 52.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O
X-ray-responsive nanocarriers for anticancer drug delivery have shown great promise for enhancing the efficacy of chemoradiotherapy. A critical challenge remains for development of such radiation-controlled drug delivery systems (DDSs), which is to minimize the required X-ray dose for triggering the cargo release. Herein, we design and fabricate an effective DDS based on diselenide block copolymers (as nanocarrier), which can be triggered to release their cargo with a reduced radiation dose of 2 Gy due to their sensitivity to both X-ray and the high level of reactive oxygen species (ROS) in the microenvironment of cancer cells. The underlying molecular mechanism is further illustrated by proton nuclear magnetic resonance (H-1 NMR) experiments and density functional theory (DFT) calculations. In vivo experiments on tumor-bearing mice validated that the loaded drugs are effectively delivered to the tumor site and exert remarkable antitumor effects (minimum tumor volume/weight) along with X-ray. Furthermore, the diselenide nanocarriers exhibit no noticeable cytotoxicity. These findings provide new insights for the de novo design of radiation-controlled DDSs for cancer chemoradiotherapy.
Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Zhang, LX; Zhang, ST; Xu, JY; Li, YY; He, JL; Yang, Y; Huynh, T; Ni, PH; Duan, GX; Yang, ZX; Zhou, RH or concate me.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles