Recently I am researching about SEMICARBAZONES; HYDROXYUREA; VIVO, Saw an article supported by the Research Council of Mazandaran University of Medical Sciences, Sari, Iran [2571]. Published in SPRINGER in DORDRECHT ,Authors: Ansari, M; Montazeri, M; Daryani, A; Farshadfar, K; Emami, S. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol. Computed Properties of C7H8O2
A new series of aryloxyacetophenone thiosemicarbazones 4a-q have been synthesized as anti-Toxoplasma gondii agents. All compounds showed significant inhibitory activity against T. gondii-infected cells (IC50 values 1.09-25.19 mu g/mL). The 4-fluorophenoxy derivative (4l) was the most potent compound with the highest selectivity toward host cells (SI = 19), being better than standard drug pyrimethamine. SAR study indicated that the concurrence of proper substituents on both aryl ring of phenoxyacetophenone is important for potency and safety profile. Further in vitro experiments with the representative compounds 4l and 4p revealed that these compounds at the concentration of 5 mu g/mL can significantly reduce the viability of T. gondii tachyzoites, as well as their infectivity rate and intracellular proliferation, comparable to those of pyrimethamine.
About m-Methoxyphenol, If you have any questions, you can contact Ansari, M; Montazeri, M; Daryani, A; Farshadfar, K; Emami, S or concate me.. Computed Properties of C7H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles