Arcadi, A; Fabrizi, G; Fochetti, A; Ghirga, F; Goggiamani, A; Iazzetti, A; Marrone, F; Mazzoccanti, G; Serraiocco, A in [Arcadi, Antonio] Univ LAquila, Dipartimento Sci Fis & Chim, Via Vetoio, I-67100 Coppito, AQ, Italy; [Fabrizi, Giancarlo; Fochetti, Andrea; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Mazzoccanti, Giulia; Serraiocco, Andrea] Sapienza Univ Roma, Dipartimento Chim & Tecnol Farmaco, Ple A Moro 5, I-00185 Rome, Italy; [Ghirga, Francesca] Ist Italian Tecnol, Ctr Life Nano Sci Sapienza, Viale Regina Elena 291, I-00161 Rome, Italy published Palladium-catalyzed Tsuji-Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles in 2021.0, Cited 122.0. Application In Synthesis of Mequinol. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.
The palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetate with N, S, O and C soft nucleophiles has been investigated. The success of the reaction is dramatically influenced by the choice of catalytic system: with nitrogen based nucleophiles the reaction works well with Pd-2(dba)(3)/dppf, while with sulfur, oxygen and carbo-nucleophiles [Pd(eta(3)-C3H5)Cl](2)/XPhos is more efficient. The regiochemical outcome shows that the nucleophilic substitution occurs only on the benzylic position of the eta(3)-(benzofuryl)methyl complex. The high to excellent yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2-substituted benzo[b]furans.
Welcome to talk about 150-76-5, If you have any questions, you can contact Arcadi, A; Fabrizi, G; Fochetti, A; Ghirga, F; Goggiamani, A; Iazzetti, A; Marrone, F; Mazzoccanti, G; Serraiocco, A or send Email.. Application In Synthesis of Mequinol
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles