On October 31, 2005, Segraves, Nathaniel L.; Crews, Phillip published an article.COA of Formula: C11H10BrNO2 The title of the article was Investigation of brominated tryptophan alkaloids from two Thorectidae sponges: Thorectandra and Smenospongia. And the article contained the following:
Chem. investigation of an NCI-DTP collection of Thorectandra sp. and a UCSC collection of Smenospongia sp. yielded six new brominated tryptophan derivatives : 6-bromo-1′-hydroxy-1′,8-dihydroaplysinopsin (e.g. IV), 6-bromo-1′-methoxy-1′,8-dihydroaplysinopsin (V), 6-bromo-1′-ethoxy-1′,8-dihydroaplysinopsin (VI), (-)-5-bromo-N,N-dimethyltryptophan (VII), (+)-5-bromohypaphorine (VIII), and 6-bromo-1H-indole-3-carboxylic acid Me ester (XI). Addnl., the known compounds aplysinopsin (I), 1′,8-dihydroaplysinopsin (II), 6-bromo-1′,8-dihydroaplysinopsin (III), (1H-indole-3-yl)acetic acid (IX), and (6-bromo-1H-indol-3-yl)acetic acid Me ester (X) were also encountered. The structures of IV-VIII and XI were confirmed on the basis of anal. of 1H and 13C (1D and 2D) NMR data as well as comparison to known compounds Compounds I, III-VIII, X, and XI were found to inhibit the growth of Staphylococcus epidermidis with either weak or moderate MICs. The experimental process involved the reaction of Methyl 2-(6-bromo-1H-indol-3-yl)acetate(cas: 152213-63-3).COA of Formula: C11H10BrNO2
The Article related to brominated tryptophan alkaloid thorectandra smenospongia antibacterial, Nonmammalian Biochemistry: Composition and Products and other aspects.COA of Formula: C11H10BrNO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles