On December 22, 2015, Seifert, Joachim; Singh, Latika; Ramsdale, Tracie Elizabeth; West, Michael Leo; Drinnan, Nicholas Barry published a patent.Name: Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside The title of the patent was Synthetic heparin pentasaccharides via glycosylation reaction using different protecting groups. And the patent contained the following:
Preparation of synthetic monosaccharides, disaccharides I, wherein X is from the group consisting of a hydroxyl group; thioalkyl, thioaryl, halogen, trichloroacetimidoyl, and ‘butyldiphenylsilyloxy, and wherein the stereochem. may be α or β; R1 is 4-methoxyphenyl, benzyl, substituted benzyl groups, alkylacyl, arylacyl, alkylarylacyl, substituted alkylacyl, substituted arylacyl, substituted alkylarylacyl, carbonate protecting groups; R2 is 4-methoxyphenyl, alkylacyl, arylacyl, alkylarylacyl, substituted alkylacyl, substituted arylacyl, substituted alkylarylacyl protecting group, carbonate protecting groups, carbamate protecting groups, or alkenyl; R3 is Me, alkyl, alkenyl, benzyl and substituted benzyl; R4 is azido, substituted amine; R5 is benzyl, substituted benzyl protecting group, allyl, allyloxycarbonyl; R4 and R5 independently can combine together to form a cyclic carbamate; and, trisaccharides, tetrasaccharides and pentasaccharides; R6 is benzyl; R7 is benzoyl, arylacyl protecting group, alkylarylacyl protecting group, substituted alkylacyl protecting group, 4-chlorobenzoyl, substituted arylacyl protecting group, substituted alkylarylacyl protecting group, allyloxycarbonyl, ethoxycarbonyl, tertbutoxycarbonyl, carbonate protecting groups, t-butyldiphenylsilyl, allyl, methoxymethyl, methoxyethyl, were prepared for use in the preparation of synthetic heparinoids. Thus, heparin pentasaccharide II was prepared via glycosylation reaction using different protecting groups. The experimental process involved the reaction of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside(cas: 130539-43-4).Name: Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside
The Article related to heparinoid synthon uronate pentasaccharide preparation glycosylation protecting group, uronate heparin oligosaccharide preparation monosaccharide disaccharide trisaccharide and other aspects.Name: Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles