Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intracellular and Drug-Resistant Mycobacteria was written by Semenya, Dorothy;Touitou, Meir;Ribeiro, Camila Maringolo;Pavan, Fernando Rogerio;Pisano, Luca;Singh, Vinayak;Chibale, Kelly;Bano, Georg;Toscani, Anita;Manetti, Fabrizio;Gianibbi, Beatrice;Castagnolo, Daniele. And the article was included in ACS Medicinal Chemistry Letters in 2022.Computed Properties of C9H6ClNO This article mentions the following:
A series of indolyl-3-methyleneamines incorporating lipophilic side chains were designed through a structural rigidification approach and synthesized for investigation as new chem. entities against Mycobacterium tuberculosis (Mtb). The screening led to the identification of a 6-chloroindole analog 7j (I) bearing an N-octyl chain and a cycloheptyl moiety, which displayed potent in vitro activity against laboratory and clin. Mtb strains, including a pre-extensively drug-resistant (pre-XDR) isolate. 7j also demonstrated a marked ability to restrict the intracellular growth of Mtb in murine macrophages. Further assays geared toward mechanism of action elucidation have thus far ruled out the involvement of various known promiscuous targets, thereby suggesting that the new indole 7j may inhibit Mtb via a unique mechanism. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Computed Properties of C9H6ClNO).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Computed Properties of C9H6ClNO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles