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1 H – indole – 2 – carbohydrazide derivative and its preparation and use. Preparation method: 1) a synthetic intermediate of the pyruvic acid ethyl ester to the nitrobenzene zong; 2) the preparation of intermediate 5 – nitro-indole – 2 – carboxylic acid ethyl ester; 3) the preparation of intermediate 5 – amino – 1 H – indole – 2 – carboxylic acid ethyl ester; 4) preparation of 5 – (4 – (pyridine – 3 – yl) pyrimidine – 2 – ylamino) – 1 H – indole – 2 – carboxylic acid ethyl ester; 5) preparation of 5 – (4 – – (pyridine – 3 – yl) pyrimidine – 2 – yl) amino) – 1 H – indole – 2 – carbohydrazide; 6) methyl asia base preparation N’ – substituted – 5 – ((4 – (pyridine – 3 – yl) pyrimidine – 2 – yl) amino) – 1 H – indole – 2 – carbohydrazide derivatives. Can be in the preparation for preventing or treating relates to CDK9 receptor related disease medicine. (by machine translation)

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles