On January 3, 2022, Shaaban, Saad; Merten, Christian; Waldmann, Herbert published an article.Electric Literature of 52537-00-5 The title of the article was Catalytic Atroposelective C7 Functionalisation of Indolines and Indoles. And the article contained the following:
Axially chiral atropisomeric compounds are widely applied in asym. catalysis and medicinal chem. In particular, axially chiral indole- and indoline-based frameworks have been recognized as important heterobiaryl classes because they are the core units of bioactive natural alkaloids, chiral ligands and bioactive compounds Among them, the synthesis of C7-substituted indole biaryls and the analogous indoline derivatives is particularly challenging, and methods for their efficient synthesis are in high demand. Transition-metal catalysis is considered one of the most efficient methods to construct atropisomers. Here, authors report the enantioselective synthesis of C7-indolino- and C7-indolo biaryl atropisomers by means of C-H functionalisation catalyzed by chiral RhJasCp complexes. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Electric Literature of 52537-00-5
The Article related to indolino indolo biaryl atropisomer preparation enantioselective, methoxyindolinecarboxamide indolobenzamide diazonaphthoquinone coupling rhodium, c−h functionalisation, atropisomers, chiral cpx complexes, indoles, indolines, rhodium and other aspects.Electric Literature of 52537-00-5
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles