Shaikh, Iqbal N.; Rahim, Abdul; Faazil, Shaikh; Adil, Syed Farooq; Assal, Mohamed E.; Hatshan, Mohammad Rafe published an article in 2021. The article was titled 《BF3-OEt2 catalyzed C3-alkylation of indole: synthesis of indolylsuccinimides and their cytotoxicity studies》, and you may find the article in Molecules.Recommanded Product: 5-Fluoro-1H-indole The information in the text is summarized as follows:
A simple and efficient BF3-OEt2 promoted C3-alkylation of indole has been developed to obtain 3-indolylsuccinimides I (R1 = H, OMe, F, Br, CN, NO2; R2 = H, Me, Bn; R3 = Me, Ph, Bn) from com. available indoles II and maleimides III, with excellent yields under mild reaction conditions. Furthermore, anti-proliferative activity of these conjugates was evaluated against HT-29 (Colorectal), Hepg2 (Liver) and A549 (Lung) human cancer cell lines. One of the compounds, I (R1 = H, R2 = R3 = Me), having N,N-Dimethylatedindolylsuccinimide is a potent congener amongst the series with IC50 value 0.02μM and 0.8μM against HT-29 and Hepg2 cell lines, resp., and compound I (R1 = R2 = H, R3 = Bn) was most active amongst the series with IC50 value 1.5μM against A549 cells. Mol. docking study and mechanism of reaction have briefly been discussed. This method is better than previous reports in view of yield and substrate scope including electron deficient indoles. After reading the article, we found that the author used 5-Fluoro-1H-indole(cas: 399-52-0Recommanded Product: 5-Fluoro-1H-indole)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Recommanded Product: 5-Fluoro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles