Derivatization of a rigid meso-substituted heptamethine cyanine dye was written by Shershov, Valeriy E.;Kuznetsova, Viktoriya E.;Miftakhov, Rinat A.;Lapa, Sergey A.;Stomahin, Andrey A.;Timofeev, Edward N.;Grechishnikova, Irina V.;Zasedatelev, Alexander S.;Chudinov, Alexander V.. And the article was included in Mendeleev Communications in 2021.Product Details of 146368-07-2 This article mentions the following:
A novel electroneutral rigid meso-sulfophenyloxy substituted heptamethine dye was synthesized in six steps. Selective derivatization of one sulfonamide group with octanedioic acid introduced the carboxy end group attached through the hexamethylene linker, which provided the dye solubility in water. Absorbance of the dye in the near IR region makes it promising for covalent labeling of biomols. In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Product Details of 146368-07-2).
1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Product Details of 146368-07-2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles