Synthesis of 3′,4′-Diaryl-4’H-spiro[indoline-3,5′-[1′,2′,4′]oxadiazol]-2-ones via DMAP-catalyzed Domino Reactions and Their Antibacterial Activity was written by Shi, Guanghao;He, Xinwei;Shang, Yongjia;Xiang, Liwei;Yang, Cheng;Han, Guang;Du, Bing. And the article was included in Chinese Journal of Chemistry in 2016.COA of Formula: C11H11NO2 This article mentions the following:
A convenient and metal-free DMAP-catalyzed domino reaction of isatins, arylamines and hydroximoyl chlorides was developed to achieve 1,3-dipolar cycloaddition of imines into aryl nitrile oxides at ambient temperature In this one-pot transformation, a 1,2,4-oxadiazole skeleton was efficiently formed. This methodol. needed no extra additives and features wide substrate scope, good functional group tolerance and mild reaction conditions. A plausible mechanism for this process was proposed. Moreover, the antibacterial activities of the products were evaluated towards Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae using the Broth microdilution method. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0COA of Formula: C11H11NO2).
5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.COA of Formula: C11H11NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles