Synthesis of N-substituted isoindolin-1-ones via palladium-catalyzed carbonylative heterocyclization of o-bromobenzyl bromide with carbon monoxide and primary amines was written by Shim, Sang Chul;Jiang, Li Hong;Lee, Dong Yub;Cho, Chan Sik. And the article was included in Bulletin of the Korean Chemical Society in 1995.Quality Control of 2-Phenylisoindolin-1-one This article mentions the following:
A convenient method for the synthesis of N-substituted isoindolin-1-ones is disclosed in palladium(0)-catalyzed heterocyclization of o-bromobenzyl bromide with carbon monoxide (CO) and primary amines in DMF at 100 闂佺娅ｉ悡? In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Quality Control of 2-Phenylisoindolin-1-one).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Quality Control of 2-Phenylisoindolin-1-one
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles