Synthetic studies toward welwitindolinone alkaloids. Tandem aldol-michael reaction to form the carbocyclic core of welwitindolinones was written by Shima, Masato;Toyota, Masahiro. And the article was included in Heterocycles in 2015.Synthetic Route of C9H8BrN This article mentions the following:
A tandem aldol-Michael reaction of silyl enol ether of indolylcyclohexanone with acetone to effectively construct a bridged ketone, which is the carbocyclic core of the welwitindolinone family. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-indole (cas: 590417-55-3Synthetic Route of C9H8BrN).
4-Bromo-1-methyl-1H-indole (cas: 590417-55-3) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C9H8BrN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles