On April 30, 2012, Sikorska, Emilia; Sobolewski, Dariusz; Kwiatkowska, Anna published an article.Recommanded Product: H-Idc-OH The title of the article was Conformational preferences of proline derivatives incorporated into vasopressin analogues: NMR and molecular modelling studies. And the article contained the following:
In this study, arginine vasopressin analogs modified with proline derivatives – indoline-2-carboxylic acid (Ica), (2S,4R)-4-(naphthalene-2-ylmethyl)pyrrolidine-2-carboxylic acid (Nmp), (2S,4S)-4-aminopyroglutamic acid (APy) and (2R,4S)-4-aminopyroglutamic acid, (Apy) – were examined using NMR spectroscopy and mol. modeling methods. The results have shown that Ica is involved in the formation of the cis peptide bond. Moreover, it reduces to a great extent the conformational flexibility of the peptide. In turn, incorporation of (2S,4R)-Nmp stabilizes the backbone conformation, which is heavily influenced by the pyrrolidine ring. However, the aromatic part of the Nmp side chain exhibits a high degree of conformational freedom. With analogs [(2S,4S)-4-aminopyroglutamic acid2-3]AVP and [(2R,4S)-4-aminopyroglutamic acid2-3]AVP, introduction of the 4-aminopyroglutamic acid reduces locally conformational space of the peptides, but it also results in weaker interactions with the dodecylphosphocholine/SDS micelle. Admittedly, both analogs are adsorbed on the micelle’s surface but they do not penetrate into its core. With analog [(2R,4S)-4-aminopyroglutamic acid2-3]AVP, the interactions between the peptide and the micelle seem to be so weak that conformational equilibrium is established between different bound states. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: H-Idc-OH
The Article related to arginine vasopressin proline derivative nmr mol modeling conformation preference, Mammalian Hormones: Structure and Structure-Activity Relations and other aspects.Recommanded Product: H-Idc-OH
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles