103858-53-3, Ethyl 6-bromoindole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
103858-53-3, Example 1 6-(4-TERT-BUTYLPHENYL)-1-(3-PHENOXYBENZYL)-3-PHENYLINDOLE-2-CARBOXYLIC acid (a) 6-(4-tert-Butylphenyl)indole-2-carboxylic acid ethyl ester A mixture of 6-BROMOINDOLE-2-CARBOXYLIC acid ethyl ester (400 mg, 1.5 mmol), 4-TERT-BUTYLPHENYLBORONIC acid (400 mg, 2.25 mmol), K3P04 (950 mg, 1.5 mmol), Pd (OAC) 2 (18 mg, 0.075 mmol), 2,2′-bis (di-tert- BUTYLPHOSPHINO)-L, l’-biphenyl (45 mg, 0.15 mmol), and toluene (9 ML) were stirred in an argon atmosphere for 30 min at room temperature, and at 100 C for 40 min using microwave irradiation. The mixture was cooled to room temperature and poured into NaHCO3 (aq. , sat. ). The mixture was extracted with EtOAc and the combined extracts were washed with water, brine and dried over NA2S04. The organic phase was then concentrated and the product purified by chromatography to give the sub-title compound (392 mg, 81%).
As the paragraph descriping shows that 103858-53-3 is playing an increasingly important role.
Reference£º
Patent; BIOLIPOX AB; MCNEENEY, Stephen, Phillip; WO2005/5415; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles