With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1074-86-8,1H-Indole-4-carbaldehyde,as a common compound, the synthetic route is as follows.
1074-86-8, General procedure: A solution of anhydrous Cu(OAc)2 (1.8 mg, 0.01 mmol) andligand 7d (4.0 mg, 0.01 mmol) in MTBE (1 mL) in a 10mL test tubeequipped with a magnetic stirring bar was stirred at room temperaturefor 30 min. Next, 20 mL DABCO (5M dissolved in n-propanol)was added, followed by stirring for 5 min. After the aldehyde(0.2 mmol) was added to the reaction mixture, we stirred themixture at 10 C for 2 min, and then 2-nitropropane (180 mL,2 mmol) was added to the tube. The reaction was stirred at 10 Cand monitored by TLC. After the complete reaction, the chiralproduct was separated by flash column chromatography (PE/EA 9/1). Enantiomeric excesses were determined by HPLC chiralcolumn.
1074-86-8 1H-Indole-4-carbaldehyde 333703, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Cai, Zedong; Lan, Ting; Ma, Pengfei; Zhang, Jingfang; Yang, Qingqing; He, Wei; Tetrahedron; vol. 75; 34; (2019);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles