With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-35-0,5-Chloro-2-methylindole,as a common compound, the synthetic route is as follows.
General procedure: Para substituted chalcones (1 equiv.) (9-16) and malononitrile (1equiv.) were stirred in acetonitrile in the presence of L-proline catalyst at room temperature for half an hour. To this reaction mixture different 2-methyl indole (0.8 equiv.) were added and was heated to 90 C on an oil bath. Reaction mixture was stirred till the completion of reaction as monitored by TLC. Afterwards, the reaction mixture was evaporated to dryness under vacumm and was partitioned between ethyl acetate and water. The combined organiclayer was dried and purified by silica gel column chromatographyto get pure products 17-29 [50]., 1075-35-0
1075-35-0 5-Chloro-2-methylindole 70636, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Gupta, Sampa; Maurya, Pooja; Upadhyay, Akanksha; Kushwaha, Pragati; Krishna, Shagun; Siddiqi, Mohammad Imran; Sashidhara, Koneni V.; Banerjee, Dibyendu; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1981 – 1996;,
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