With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118414-82-7,MK-886,as a common compound, the synthetic route is as follows.,118414-82-7
To 3-[3-tert-butylsulfanyl-l-(4-chloro-benzyl)-5-isopropyl-lH-indol-2-yl]-2,2-dimethyl- propionic acid (prepared according to the procedures described in US patent 5,081, 138 issued Jan 14, 1992; 0.25g, 0.53mmol) suspended in CH2CI2 (5mL) was added oxalyl chloride (48uL, 0.56mmol) and catalytic DMF. The reaction was stirred at room temperature for 3 hours, and then concentrated to give 1-1, which was used without further purification.
118414-82-7 MK-886 3651377, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; AUTOIMMUNE PHARMA LLC; BENISON, Jeffrey; (157 pag.)WO2018/152405; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles