SDS of cas: 120-14-9. Recently I am researching about ALPHA-LIPOIC ACID; NF-KAPPA-B; INDUCED NEPHROTOXICITY; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; STAT3; ANTIOXIDANT; DESIGN; INTERLEUKIN-6; CYTOKINES, Saw an article supported by the Deanship of Scientific Research at King Saud UniversityKing Saud University [RGP-193]. Published in NATURE RESEARCH in BERLIN ,Authors: Razak, S; Afsar, T; Bibi, N; Abulmeaty, M; Qamar, W; Almajwal, A; Inam, A; Al Disi, D; Shabbir, M; Bhat, MA. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde
Cisplatin is an efficient anticancer drug against various types of cancers however, its usage involves side effects. We investigated the mechanisms of action of indole derivative, 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N’-[(E)-(3-nitrophenyl) methylidene] acetohydrazide (MMINA) against anticancer drug (cisplatin) induced organ damage using a rodent model. MMINA treatment reversed Cisplatin-induced NO and malondialdehyde (MDA) augmentation while boosted the activity of glutathione peroxidase (GPx), and superoxide dismutase (SOD). The animals were divided into five groups (n=7). Group1: Control (Normal) group, Group 2: DMSO group, Group 3: cisplatin group, Group 4: cisplatin+MMINA group, Group 5: MMINA group. MMINA treatment normalized plasma levels of biochemical enzymes. We observed a significant decrease in CD4(+)COX-2, STAT3, and TNF-alpha cell population in whole blood after MMINA dosage. MMINA downregulated the expression of various signal transduction pathways regulating the genes involved in inflammation i.e. NF-kappa B, STAT-3, IL-1, COX-2, iNOS, and TNF-alpha. The protein expression of these regulatory factors was also downregulated in the liver, kidney, heart, and brain. In silico docking and dynamic simulations data were in agreement with the experimental findings. The physiochemical properties of MMINA predicted it as a good drug-like molecule and its mechanism of action is predictably through inhibition of ROS and inflammation.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles