With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133831-28-4,Methyl 3-Formylindole-6-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 2a(100 mg, 0.49 mmol) in dry DMF (2 ml) was added NaH (60%, 22 mg,0.54 mmol) at 0 C under argon and then stirred at room temperature for 1 h.The reaction solution was cooled to 0 C, benzoyl chloride (0.07 ml,0.54 mmol) was added and then stirred at room temperature overnight. The reaction solution was poured into H2O (20 ml), and the precipitate was filtered.The crude product was purified by column chromatography on silica gel using EtOAc/PE (1/8, V/V) as elute to give 6a as a white solid (107 mg, 71%),, 133831-28-4
The synthetic route of 133831-28-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Hong, Wei; Li, Jingyang; Chang, Zhe; Tan, Xiaoli; Yang, Hao; Ouyang, Yifan; Yang, Yanhui; Kaur, Sargit; Paterson, Ian C; Ngeow, Yun Fong; Wang, Hao; Journal of Antibiotics; vol. 70; 7; (2017); p. 832 – 844;,
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