With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13544-43-9,6-(Trifluoromethyl)-1H-indole,as a common compound, the synthetic route is as follows.
1-(p-tolylsulfonyl}-6-(trifluoromethyl)indole; 6-Trifluoromethylindole (2.082 g; 10.908 mmol; 1.00 eq.) was dissolved intoluene (30.000 ml; 283.265 mmol; 25.97 eq.). Tetra-n-butylammoniumhydrogensulfat (555.541 mg; 1.636 mmol; 0.15 eq.), NaOH solution 32%(30.000 ml; 324.024 mmol; 29.71 eq.) and toluene-4-sulfonylchloride (3.183 g; 16.362 mmol; 1.50 eq.) were added at ooc. The solution was stirred for 14 h in a thawing ice bath. The reaction mixture was diluted with toluene and water,the organic layer was washed twice with a saturated solution of ammonia and1 x with water. The organic layer was dried over MgS04, filtered andconcentrated under reduced pressure. This gives 4 g (95%) of the titlecompound as a brown solid; HPLC MS (Method G): (M+H) 340; Rt 2.601 min.
The synthetic route of 13544-43-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK PATENT GMBH; BURGDORF, Lars; KUHN, Daniel; ROSS, Tatjana; DEUTSCH, Carl; WO2014/23385; (2014); A1;,
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