With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14430-23-0,5,6-Dimethoxyindole,as a common compound, the synthetic route is as follows.
General procedure: Compounds 4 a-d were prepared according a previously reportedprocedure [40,49]. The appropriate indole 3 a-d (1 mmol)was added to a solution of phosphoryl chloride (0.92 mL, 10 mmol)in dimethylacetamide (2.79 mL, 30 mmol) and the resultingmixture was stirred at room temperature for 24 h. Then, the reactionmixturewas basified with sodium hydroxide solution (4N) andextracted with EtOAc (3 10 mL). The organic phases were driedover Na2SO4 and the solvent removed under reduced pressure. Thefinal compounds were obtained by crystallization with amixture ofEt2O and DCM.
The synthetic route of 14430-23-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Ferro, Stefania; De Luca, Laura; Germano, Maria Paola; Buemi, Maria Rosa; Ielo, Laura; Certo, Giovanna; Kanteev, Margarita; Fishman, Ayelet; Rapisarda, Antonio; Gitto, Rosaria; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 591 – 598;,
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