With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14618-45-2,3-(Trifluoroacetyl)indole,as a common compound, the synthetic route is as follows.
To a chilled (-780C) solution of 2.67 g (9.20 mmol) 5-bromo-l-(4-fluorophenyl)-lH-indazole in 10 mL of anhydrous TetaF was added 7.36 mL (18.40 mmol) of a 2.5 M solution of n- butyllithium in hexane followed by a solution of 1.00 g (4.69 mmol) of 2,2,2-trifluoro-l-(lH- indol-3-yl)ethanone in 5 mL of TetaF in one portion. The reaction was then stirred at -78C for 30 minutes and quenched with 5 mL of water. The mixture was warmed to room temperature and extracted with ethyl acetate. The combined organic layer was washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography (20%-40% ethyl acetate in hexanes). The major fractions were combined and concentrated to afford 978 mg of 2,2,2-trifluoro-l-[l-(4-fluorophenyl)-lH-indazol-5-yl]-l-(lH- indol-3-yl)ethanol. MS m/z 426.39 (MH+).
14618-45-2, The synthetic route of 14618-45-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/70507; (2008); A2;,
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