An article Biscoumarin-pyrimidine conjugates as potent anticancer agents and binding mechanism of hit candidate with human serum albumin WOS:000570221000001 published article about DNA CLEAVAGE; APOPTOSIS-INDUCTION; IN-VITRO; COUMARIN; DERIVATIVES; CYTOTOXICITY; ANTITUMOR; HYBRIDS; DESIGN; HALOGENATION in [Reddy, Dinesh S.; Kongot, Manasa; Kumar, Amit] Jain Univ, Ctr Nano & Mat Sci, Jain Global Campus, Bangalore 562112, Karnataka, India; [Singh, Vishal; Singhal, Nitin K.] Natl Agri Food Biotechnol Inst, Mohali, India; [Siddiquee, Md. Abrar; Patel, Rajan] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, Biophys Chem Lab, New Delhi, India; [Avecilla, Fernando] Univ A Coruna, Fac Ciencias, Dept Quim, Ctr Invest Cient Avanzadas CICA,Grp Xenomar, La Coruna, Spain in 2021, Cited 56. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Computed Properties of C7H8O2
In our continuing efforts to develop therapeutically active coumarin-based compounds, a series of new C4-C4 ‘ biscoumarin-pyrimidine conjugates (1a-l) was synthesizedviaS(N)2 reaction of substituted 4-bromomethyl coumarin with thymine. All compounds were characterized using spectroscopic techniques, that is, attenuated total reflection infrared (ATR-IR), CHN elemental analysis, and(1)H and(13)C NMR (nuclear magnetic resonance). In addition, the structure of compound1d(1,3-bis[(7-chloro-2-oxo-2H-chromen-4-yl)methyl]-5-methylpyrimidine-2,4(1H,3H)-dione) was established through X-ray crystallography. Compounds1a-lwere screened for in vitro anticancer activity against C6 rat glioma cells. Among the screened compounds, 1,3-bis[(6-chloro-2-oxo-2H-chromen-4-yl)methyl]-5-methylpyrimidine-2,4(1H,3H)-dione (1c) was identified as the best antiproliferative candidate, exhibiting an IC(50)value of 4.85 mu M. All the compounds (1a-l) were found to be nontoxic toward healthy human embryonic kidney cells (HEK293), indicating their selective nature. In addition, the most active compound (1c) displayed strong binding interactions with the drug carrier protein, human serum albumin, and exhibited good solution stability at biological pH conditions. Fluorescence, UV-visible spectrophotometry and molecular modeling methodologies were employed for studying the interaction mechanism of compound1cwith protein.
Computed Properties of C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Reddy, DS; Kongot, M; Singh, V; Siddiquee, MA; Patel, R; Singhal, NK; Avecilla, F; Kumar, A or concate me.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles