15903-94-3, 6-(Benzyloxy)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Ethylmagnesium bromide (44 mL, 134.5 mmol, 3.OM solution in Et20) was added dropwise at 0 ¡ãC to a solution of 6-(benzyloxy)-1H-indole (10 g, 44.8 mmol) over a period of 1 h in DCM (100 mL) under an atmosphere of argon. The resultant reaction mixture was warmed to room temperature and stirred for an additional 1 h. The above reaction mixture was cooled to 0 ¡ãC and treated with a solution of (9H-fluoren-9- yl)methyl (R)-(1-chloro-1-oxopropan-2-yl)carbamate (22 g, 67.2 mmol, crude) in DCM (100 mL) under an atmosphere of argon. After the addition was complete, the reaction was warmed to room temperature and stirred at rt for 12 h. The reaction mixture was cooled back to 0 ¡ãC and the excess of unreacted Grignard reagent was destroyed with aqueous HC1 (200 mL, 2N). The organic layer was separated and the aqueous layer was extracted with CH2C12 (2 x 200 mL). The combined organic layer was washed with water followed by brine, dried over sodium sulfate, filtered and concentrated to afford (R)-(9H-Fluoren-9-yl)methyl 1 -(6-(benzyloxy)- 1H-indol-3 -yl)-l -oxopropan-2-ylcarbamate (22.0 g, 42.6 mmol, crude) as abrown liquid. MS (ESI) m/z 517.35 [M+H] .
As the paragraph descriping shows that 15903-94-3 is playing an increasingly important role.
Reference£º
Patent; KALYRA PHARMACEUTICALS, INC.; HUANG, Peter, Qinhua; SLEE, Deborah, Helen; HEGDE, Sayee, Gajanan; HOPKINS, Chad, Daniel; BUNKER, Kevin, Duane; PINCHMAN, Joseph, Robert; SIT, Rakesh, Kumar; (137 pag.)WO2017/172957; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles