With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16502-01-5,2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole,as a common compound, the synthetic route is as follows.
To a stirred solution of tryptoline (2,3,4,9-tetrahydro-1 /-/-pyrido[4,3-b]indole) (150 g, 0.871 mol) in THF (1 .5 L) at 0 C, triethylamine (243 ml_, 1 .74 mol) and di-ferf-butyl dicarbonate (228 g, 1.04 mol) were added and the reaction mixture was stirred at 25 C for 12 h. After the completion of the reaction (monitored by TLC), water was added to the reaction mixture under ice-cooling and extracted with ethyl acetate (2 x 500 ml_). The combined organic extracts were washed with brine (1 x 250 ml_), dried over anhydrous Na2S04,filtered and evaporated under reduced pressure to get the crude product. The crude material was stirred with diethyl ether (200 mL) and the solid thus obtained was filtered, washed with diethyl ether (2 x 100 mL) and dried to afford the title compound as brown solid (200 g, 84 %).1H-NMR (400 MHz, CDCI3) d = 7.94 (br-s, 1 H), 7.51 (d, J = 7.60 Hz, 1 H), 7.33-7.34 (m, 1 H), 7.1 1 -7.13 (m, 2H), 4.67 (s, 2H), 3.79 (br-s, 2H), 2.83 (br-s, 2H), 1.53 (s, 9H).MS: 273.2 (M+H)+., 16502-01-5
16502-01-5 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole 107838, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (0 pag.)WO2019/233883; (2019); A1;,
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