166104-20-7, 1-Boc-5-Aminoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 2-chioro-3-nitro-6-(trifluoromethyl)pyridine (1.0 g, 4.4 rnmoi)and tert-hulyl 5-amino-1H-indoie-1-carboxylate (0.59 g, 4.4 mmol) in DMF (20 mL) was heated at 100 ¡ãC for 3 h. 4-Fluorobenzaldehyde (0.60 g. 4.9 mmol) was added to the mixture and the reaction was stirred for 30 mm followed by addition of sodium dithionite (2.3g. 13.2 rnrnol). After 12 h at100 ¡ãC the reaction was cooled, diluted with EtOAc (100 mnL), and washed with F120 (50 mL x 3). The organic layer was dried (Na2504), and concentrated in vacuo. Purification (FCC. 5i02, EtOAc/hexanes) afforded the title compound (1.1 g, 50percent). MS ESI): mass caicd. for C76H20F4N407, 496.1; mn/z found, 497.0 [M?++{it., 166104-20-7
As the paragraph descriping shows that 166104-20-7 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BERRY, Cynthia G.B.; CHEN, Gang; JOURDAN, Fabrice Loic; LEBOLD, Terry Patrick; LIN, David Wei; PENA PINON, Miguel Angel; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; WU, Dongpei; ZHANG, Wei; AMERIKS, Michael K.; (407 pag.)WO2016/176460; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles