With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-57-3,Ethyl 5-nitro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
Example 10: Synthesis of 1-BENZYL-3-(4-TE7F-BUTYLPHENYL)-5-(LH-PYRROL-L-YL)- LH-INDOLE-2-CARBOXYLIC acid; [0122] Step 1:; A solution of N-BROMOSUCCINIMIDE (0.83 g, 4.7 mmol) in DMF (5 ML) was added dropwise to a stirred solution of ethyl 5-nitro-1H-indole-2-carboxylate (1.0 g, 4.27 mmol) in DMF (5 mL) at 0-5C. After the addition was completed, the reaction was warmed to room temperature and stirring was continued for an additional 1.5 h. The reaction mixture was poured over ice water and the resulting precipitate was collected and dried. The dried solid was re-dissolved in DMF (10 ML) and benzyl bromide (0.68 g, 4.0 mmol) and CS2CO3 (6.56 g, 20 mmol) were added successively. The reaction was stirred for overnight and then diluted with water. The product was extracted with ethyl acetate, dried over magnesium sulfate. Recrystalization from ethyl acetate and hexane gave 0.99 g (57%) of ethyl 1-BENZYL-3-BROMO-5- nitro-1 H-indole-2-carboxylate as an off-white solid : 1H NMR (DMSO-D6) No. 1. 28 (t, J = 7.0 Hz, 3 H), 4.35 (q, J = 7. 0 HZ, 2 H), 5.90 (s, 2 H), 7.00-7. 10 (m, 2 H), 7.20-7. 35 (m, 3 H), 7.95 (d, J= 9.3 Hz, 1 H), 8.25 (dd, J = 9.3, 2.0 Hz, 1 H), 8.48 (d, J = 2.0 Hz, 1 H); MS (ESI) m/z 403/405 (MH+).
16732-57-3 Ethyl 5-nitro-1H-indole-2-carboxylate 280312, aindole-building-block compound, is more and more widely used in various.
Reference£º
Patent; WYETH; WO2005/30756; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles