With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-70-0,Ethyl 5-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
a) 5-Pyridin-3-yl-lH-indole-2-carboxylic acid ethyl ester 5-Bromo-lH-indole-2-carboxylic acid ethyl ester (5.0 g), 3-tributylstannylpyridine (7.552 g), and bis-(triphenylphosphin)-palladium(II)-dichlorid (0.131 mg) were suspended in dioxane (10 mL) and refluxed at 120C overnight. Still starting material left, another bis-(triphenylphosphin)- palladium(II)-dichlorid (0.131 mg) was added, reaction was refluxed over the weekend. The reaction mixture was evaporated, the residue was purified by column chromatography on basic silica gel using heptane / ethyl acetate (7:3) and crystallized in diethylether to yield the title compound as a white solid (1.454 g, 29 %). MS ISP (m/e): 267.1 (100) [(M+H)+].
16732-70-0, 16732-70-0 Ethyl 5-bromo-1H-indole-2-carboxylate 259091, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BAUMANN, Karlheinz; FLOHR, Alexander; JOLIDON, Synese; KNUST, Henner; LUEBBERS, Thomas; NETTEKOVEN, Matthias; WO2014/60386; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles