1953-54-4, 5-Hydroxyindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: N-phenyl glyoxylamide 1a (1.0 mmol), indole 2a (1.1 mmol), and 20 mmol% FeSO4 were added to 6 mL of C2H5OH and then the mixture was stirred at room temperature for 0.5 h. After the completion of the reaction (monitored by TLC analysis), the mixture was diluted with water and extracted with ethyl acetate (20 mL ¡Á 4). The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and the solvent was evaporated to dryness. The crude residue was purified by flash chromatography on silica (dichloromethane/methanol=80/1) to afford pure 2-hydroxy-2-(1H-indol-3-yl)-N-phenylacetamide 3a as a yellow solid (247.6 mg, 93% yield)., 1953-54-4
As the paragraph descriping shows that 1953-54-4 is playing an increasingly important role.
Reference£º
Article; Zheng, Yang; Li, Ren-Jun; Zhan, Zhen; Zhou, Yan; Hai, Li; Wu, Yong; Chinese Chemical Letters; vol. 27; 1; (2016); p. 41 – 46;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles