With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2338-71-8,5-Fluoro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.
Add III-6 (0.50g, 3.07mmol), DMAP (75mg, 0.61mmol), DIEA (1.52mL, 9.21mmol) to 100mL three-necked flask, stir and dissolve with 10mL acetonitrile, slowly add at 05C Benzene 4-trifluoromethylbenzenesulfonyl chloride (IV-7, 0.90 g, 3.68 mmol) in 10 mL of acetonitrile solution, after completion of the addition, stirring was continued for 2 h under low temperature conditions.TLC monitoring of raw material reactionsCompletely, concentrate the reaction solution, dissolve it with 20 mL of ethyl acetate, wash with 25 mL of water, and extract twice with ethyl acetate (15 mL¡Á2)The organic phase is washed with a saturated sodium chloride solution and dried over anhydrous sodium sulfate; suction filtered, and the filtrate is dried and then subjected to column chromatography ( petroleum ether:Ethyl acetate = 10:1 rinse),After drying, 0.91 g of khaki solid V-15 was obtained.The yield was 80.25%., 2338-71-8
As the paragraph descriping shows that 2338-71-8 is playing an increasingly important role.
Reference£º
Patent; China Pharmaceutical University; Xu Yungen; He Guangchao; Huang Qungang; Liang Tingting; Zhang Shan; Zhu Qihua; (35 pag.)CN109942545; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles